About BIG-KP
This knowledge portal provides a platform for accelerating genetic discoveries in the human brain.
This portal is under active construction. We aim to cover the full spectrum of structural and functional traits from different imaging modalities.
News: we have a newly-built twin website that covers imaging traits for the heart http://Heartkp.org.
We have consistently analyzed genetics and neuroimaging data of more than 65,000 subjects from
Eye-brain connections revealed by multimodal retinal and brain imaging genetics (2024). Nature Communications, 15, 6064. LINK
The pivotal role of the X-chromosome in the genetic architecture of the human brain (2024). Science Advances, in press. . LINK
Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images. Science 380, abn6598 (2023). LINK.
Genetic influences on the shape of brain ventricular and subcortical structures (2022). medRxiv, 22279691. LINK
Common variants contribute to intrinsic human brain function networks (2022). Nature Genetics. LINK
Genetic influences on the intrinsic and extrinsic functional organizations of the cerebral cortex (2021). medRxiv, 21261187. LINK
Common genetic variation influencing human white matter microstructure (2021). Science, 372-6548. LINK
Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits (2021). Nature Communications, 842872. LINK
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits (2019). Nature Genetics, 51(11), 1637-1644. LINK
Large-scale GWAS reveals genetic architecture of brain white matter microstructure and genetic overlap with cognitive and mental health traits (n= 17,706) (2019). Molecular Psychiatry, in press. LINK
Heritability of regional brain volumes in large-scale neuroimaging and genetic studies (2018). Cerebral Cortex, 29(7), 2904-2914. LINK
We make our research results publicly available by building the following resources.
If you are interested in other summary-level data from our analyses or have any questions or comments, feel free to contact Bingxin Zhao (bxzhao@upenn.edu) or Hongtu Zhu (htzhu@email.unc.edu).
1. Imaging Genetics Online Server
We build a GWAS browser using the PheWeb tool to explore GWAS results for massive functional, structural, and diffusion neuroimaging traits. Currently, we support GWAS results of 2104 traits trained in the UKB British cohort (n~34,000), including
- 635 ENIGMA-DTI parameters of brain white matter (diffusion MRI)
- 376 ANTS regional brain volumes (structural MRI)
- 191 ICA-based functional MRI traits (rs-fMRI(ICA))
- 309 parcellation-based functional MRI (task/rs-fMRI(Glasser360))
- 82 Heart imaging traits (CMR) (More info visit our Heartkp.org LINK )
- 294 Shape traits
- 217 Eye imaging traits
2. GWAS Summary Statistics Data Download
The GWAS summary statistics for 101 ANTS regional brain volumes, 635 ENIGMA-DTI parameters, 191 ICA-based amplitude (75) and functional connectivity traits (116), 309 parcellation-based functional MRI traits, 82 Heart imaging traits, and 382 shape imaging traits have been made available for download. Download the data HERE.
