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This knowledge portal provides a platform for accelerating genetic discoveries in the human brain.

This portal is under active constructions. We aim to cover the full spectrum of structural and functional traits from different imaging modalities.


We have consistently analyzed genetics and neuroimaging data of more than 40,000 subjects from

 

 

 

Publications (2018+)

Common variants contribute to intrinsic functional architecture of human brain (2020). bioRxiv, 229914. LINK

Common genetic variation influencing human white matter microstructure (2020). bioRxiv, 112409. LINK

Transcriptome-wide association analysis of 211 neuroimaging traits identifies new genes for brain structures and yields insights into the gene-level pleiotropy with other complex traits (2019). bioRxiv, 842872. LINK

Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits (2019). Nature Genetics51(11), 1637-1644. LINK

Large-scale GWAS reveals genetic architecture of brain white matter microstructure and genetic overlap with cognitive and mental health traits (n= 17,706) (2019). Molecular Psychiatry, in press. LINK

Heritability of regional brain volumes in large-scale neuroimaging and genetic studies (2018). Cerebral Cortex29(7), 2904-2914. LINK

 

We make our research results publicly available by building the following resources.

If you are interested in other summary-level data from our analyses or have any questions or comments, feel free to contact Bingxin Zhao (bingxin@purdue.edu) or Hongtu Zhu (htzhu@email.unc.edu).

1. Imaging Genetics Online Server

We build a GWAS browser using the PheWeb tool to explore GWAS results for massive functional, structural, and diffusion neuroimaging traits. Currently, we support GWAS results of 516 traits trained in the UKB British cohort (n~34,000), including

  1. 215 ENIGMA-DTI parameters of brain white matter (diffusion MRI)
  2. 101 ANTS regional brain volumes (structural MRI)
  3. 200 ICA-based amplitude and functional connectivity traits (resting-state fMRI)     Check this LINK.


2. GWAS Summary Statistics Data Download

The GWAS summary statistics for 101 ANTS brain ROI volumes, 215 ENIGMA-DTI parameters, and 200 ICA-based amplitude and functional connectivity traits have been made available for download. Download the data HERE.

 

 

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