This knowledge portal provides a platform for accelerating genetic discoveries in the human brain.
This portal is under active constructions. We aim to cover the full spectrum of structural and functional traits from different imaging modalities.
We have consistently analyzed genetics and neuroimaging data of more than 40,000 subjects from
Common variants contribute to intrinsic functional architecture of human brain (2020). bioRxiv, 229914. LINK
Common genetic variation influencing human white matter microstructure (2020). bioRxiv, 112409. LINK
Transcriptome-wide association analysis of 211 neuroimaging traits identifies new genes for brain structures and yields insights into the gene-level pleiotropy with other complex traits (2019). bioRxiv, 842872. LINK
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits (2019). Nature Genetics, 51(11), 1637-1644. LINK
Large-scale GWAS reveals genetic architecture of brain white matter microstructure and genetic overlap with cognitive and mental health traits (n= 17,706) (2019). Molecular Psychiatry, in press. LINK
Heritability of regional brain volumes in large-scale neuroimaging and genetic studies (2018). Cerebral Cortex, 29(7), 2904-2914. LINK
We make our research results publicly available by building the following resources.
If you are interested in other summary-level data from our analyses or have any questions or comments, feel free to contact Bingxin Zhao (email@example.com) or Hongtu Zhu (firstname.lastname@example.org).
We build a GWAS browser using the PheWeb tool to explore GWAS results for massive functional, structural, and diffusion neuroimaging traits. Currently, we support GWAS results of 516 traits trained in the UKB British cohort (n~34,000), including
- 215 ENIGMA-DTI parameters of brain white matter (diffusion MRI)
- 101 ANTS regional brain volumes (structural MRI)
- 200 ICA-based amplitude and functional connectivity traits (resting-state fMRI) Check this LINK.
The GWAS summary statistics for 101 ANTS brain ROI volumes, 215 ENIGMA-DTI parameters, and 200 ICA-based amplitude and functional connectivity traits have been made available for download. Download the data HERE.